Protein Kinase A and B-Raf Mediate Extracellular Signal-Regulated Kinase Activation by Thyrotropin
نویسندگان
چکیده
منابع مشابه
Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin.
Thyrotropin (TSH) regulates thyroid cell proliferation and function through cAMP-mediated signaling pathways that activate protein kinase A (PKA) and Epac/Rap1. The respective roles of PKA versus Epac/Rap1 in TSH signaling remain unclear. We set out to determine whether PKA and/or Rap1 mediate extracellular signal-regulated kinase (ERK) activation by TSH. Neither blocking Rap1 activity nor sile...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2009
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.109.060129